HYPOXIA-RESPONSIVE NANOREACTORS BASED ON SELF-ENHANCED PHOTODYNAMIC SENSITIZATION AND TRIGGERED FERROPTOSIS FOR CANCER SYNERGISTIC THERAPY

Hypoxia-responsive nanoreactors based on self-enhanced photodynamic sensitization and triggered ferroptosis for cancer synergistic therapy

Abstract Background Photodynamic therapy (PDT), a typical reactive oxygen species (ROS)-dependent treatment with high controllability, has emerged as an alternative cancer therapy modality but its therapeutic efficacy is still unsatisfactory due to the limited light penetration and constant oxygen consumption.With the development of another ROS-dep

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Seasonal and circadian rhythms of clerodane diterpenes and glycosylated flavonoids in two varieties of Casearia sylvestris Sw. (Salicaceae)

Casearia sylvestris Sw.(Salicaceae) is noted for its morphological and chemical plasticity and pharmacological properties.The present study investigates two of its varieties: C.sylvestris var.sylvestris, predominant in dense and humid forests and Cleaner/Disinfectant ecotones and characterized by clerodane diterpenes; and C.sylvestris var.lingua, m

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